李繼喜

發布時間：2021-07-07瀏覽次數：9386

教師基本信息

姓名：李繼喜（Jixi Li）

職稱：教授（Professor）

職務：上海市工業菌株工程研究中心副主任（Deputy Director of Shanghai Industrial Strain Engineering Research Center）

電子郵箱：lijixi@fudan.edu.cn

辦公地點：狗万外围充值 江灣校區生科大樓B201室（Building B201, School of Life Sciences, Fudan University）

辦公電話：021-31246539


研究方向

細胞死亡與炎症性疾病

聚焦於病原體（病毒、細菌等）感染引起的細胞程序性壞死及焦亡的調控機製，以及細胞死亡引起的免疫應答和組織損傷研究，以期闡明壞死及焦亡在各種疾病如惡性腫瘤、自身免疫性疾病、神經退行性疾病（阿爾茨海默病、帕金森病等）中發揮功能的作用機理；係統整合生物化學、結構生物學、細胞生物學及小鼠模型等技術和方法，開發基於細胞死亡相關疾病的幹預及治療性藥物。

歡迎有誌於從事上述研究的博士後、研究生、研究助理加盟我們的研究團隊（長期有效）。

Cell Death and Immune Response.

We are currently focusing on studying the regulatory mechanism of cell necroptosis and pyroptosis. Also, we are interested in revealing the molecular mechanism of immune responses caused by inflammatory cell death, which involved in various diseases including malignant tumors, autoimmune diseases, and neurodegenerative diseases. We are systematically integrating structural biology, biochemistry, mouse models, and other technologies to develop related interventions and therapeutic drugs based on cell inflammatory necrosis.

個人簡介

男，湖南郴州人。狗万外围充值 教授（二級）、博士生導師。2000年浙江大學生物科學與技術係本科畢業，2003年獲浙江大學生物物理碩士學位，2006年獲狗万外围充值 遺傳學博士學位。2006-2014年先後在美國加州理工學院（Alexander Varshavsky教授）、康奈爾大學醫學院、哈佛大學醫學院/波士頓兒童醫院（Hao Wu教授）從事博士後研究工作。2014年加入万博英超狼队网官方网 ，目前任上海市工業菌株工程研究中心副主任，遺傳工程國家重點實驗室課題組長，狗万外围充值 附屬華山醫院雙聘教授。

科技部國家重點研發計劃“蛋白質機器與生命過程調控”重點專項（2016）及“病原學與防疫技術體係研究”重點專項（2021）首席科學家；入選上海市優秀學術帶頭人（2020），國家海外高層次人才計劃（2015），上海市‘東方學者’特聘教授（2014）。

共在Cell、Immunity、Nat Commun、PNAS、Mol Neurodegener等國際著名期刊上發表SCI論文85篇，通訊作者33篇，他引4000餘次；以第一發明人獲授權發明專利12項。近年來以項目負責人身份主持科技部國家重點研發計劃（2項）、國家自然科學基金（4項）及上海市科委創新項目在內10餘項科研項目。任中國細胞生物學會細胞死亡研究分會常務委員、上海市生物物理學會理事。

Personal profile:

B.S. Department of Biological Science and Technology, Zhejiang University, China 2000

M.S. Biophysics, Zhejiang University, China 2003

Ph.D. Genetics, Fudan University, China 2006

2006-2008, Postdoc Fellow, Caltech, USA (with Prof. Alexander Varshavsky)

2008-2012, Postdoc Associate, Cornell Medical School, USA (with Prof. Hao Wu)

2012-2014, Research Fellow, Harvard Medical School/Children’s Hospital Boston, USA (with Prof. Hao Wu)

2014-present, Full Professor, School of Life Sciences, Fudan University

2018-present, Adjunct professor, Huashan Hospital affiliated with Fudan University

Memberships:

The Cell Death Research Committee of the Chinese Society of Cell Biology;

The council member of the Shanghai Biophysical Society;

Journal Editor of Cells;


獲獎情況

中國海洋科學技術二等獎（2022），浙江省海洋科技進步二等獎（2021），狗万外围充值 卓識傑出人才（2020），狗万外围充值 金龍魚合成生物學者獎（2020）、万博英超狼队网官方网 院長獎（2017、2021），狗万外围充值 複星醫藥獎教金（2016、2017、2020、2022），哈佛大學華人生命科學年度傑出研究獎（2013）。

Chief Scientist of the National Key R&D Project of the Ministry of Science and Technology (2016, 2021)

Shanghai Outstanding Academic Leader (2020)

Shanghai Distinguished Professor "Oriental Scholar" (2014)

The Marine Science and Technology Award of Zhejiang Province (ranked second, 2020)

Outstanding Talent Program--"Zhuoshi", Fudan University (2020)

Golden Dragon Fish Synthetic Biologist Award, Fudan University (2020)

Fosun Pharmaceutical Award, Fudan University (2016, 2017, 2020, 2022)


授課情況：

《改變生活的生物技術》《生命科學研究設計與實踐》（本科生榮譽課程）、《現代生物學基礎與前沿II-遺傳和發育生物學》、《結構生物學進展》

"Life Science Research Design and Practice" (undergraduate honorary course), "Basis and Frontier of Modern Biology II-Genetics and Developmental Biology", "Progress in Structural Biology"


招生專業：生物化學與生物物理（Biochemistry and Biophysics）、免疫學（Immunity）


代表性論文和論著：

細胞死亡與免疫應答領域（*：通訊作者）：

  1. Geng L, Gao W, Saiyin H, Li Y, Zeng Y, Zhang Z, Li X, Liu Z, Gao Q, An P, Jiang N, Yu X, Chen X, Li S, Chen L, Lu B, Li, A, Chen G, Shen Y, Zhang H, Tian M, Zhang Z*, Li J*. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease. Molecular Neurodegeneration 2023 Dec 1; 18:94; doi: 10.1186/s13024-023-00686-5

  2. Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X*, Li J*. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differentiation 2022 Feb;29(2):439-450.

  3. Mei P, Xie F, Pan J, Wang S, Gao W, Ge R, Gao B, Gao S, Chen X, Wang Y, Wu J, Ding C, Li J*. E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis. Cell Death Differentiation 2021 Oct;28(10):2888-2899.

  4. Gao W, Li Y, Zhang T, Lu J, Pan J, Qi Q, Dong S, Chen X, Su Z*, Li J*.  Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma.J Inflammation Research 2022 April 28; 15:2731-2743

  5. Chen Z, Li Z, Hu X, Xie F, Kuang S, Zhan B, Gao W, Chen X, Gao S, Li Y, Wang Y, Qian F, Ding C, Gan J, Ji C, Xu XW, Zhou Z, Huang J, He HH, Li J*. Structural basis of human helicase DDX21 in RNA binding, unwinding, and antiviral signal activation. Advanced Science 2020 Jun 8;7(14):2000532. (Inside Front Cover)

  6. Mompeán M#, Li W#, Li J#, Laage S, Siemer AB, Bozkurt G, Wu H, Mcdermott A. The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-amyloid Signaling Complex. Cell 2018 May 17;173(5):1244-1253. (#: co-first author)

  7. Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H*, Li J*, Silverman N*. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling. Immunity. 2017 Oct 17;47(4):635-647.

  8. Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J*. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.  Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10642-10647.

  9. Yin Q, Fu T, Li J*, Wu H*. Structural Biology of Innate Immunity. Annual Review of Immunology 2015 Mar 21; 33:393-416.

  10. Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis. Cell.2012 Jul 20;150(2):339-50. （ESI高被引論文，Highlighted by Nat Rev Mol Cell Biol）

病原體感染領域（*：通訊作者）

  1. Bao L, Hu J, Zhan B, Chi M, Li Z, Wang S, Shan C, Zhao Z, Guo Y, Ding X, Ji C, Tao S, Ni T, Zhang X*, Zhao G*, Li J*. Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism. Nature Communications 2023 Apr 20; 14:2280. 10.1038/s41467-023-38045-z

  2. Wang X, Jiang S, Jiang S, Li X, Ai J, Lin K, Lv S, Zhang S, Li M, He X, Li D, Li C, Zhao C, Zhao X, Qiao R, Cui Y, Chen Y, Li J, Cai G,Li J*, Dai L*, Hu Z*, Zhang W*, Zhang Y*, Wang P*.Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China. Cell Discovery 2023 Jun 27; 9(64)

  3. Wang S, Gao B, Chen A, Zhang Z, Wang S, Lv L, Zhao G*, Li J*. Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis. Frontiers Microbiology 2023 Mar 1;14:1137279.

  4. Zhan B, Gao Y, Gao W, Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G*, Li J*. Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis. Communications Biology 2022 Oct 3;5(1):1052.

  5. Hu Z, Zhang C, Wang S, Gao S, Wei J, Li M, Hou L, Mao H, Wei Y, Qi T, Liu H, Liu D, Lan F, Lu D, Wang H*, Li J*, Wang Y*. Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic Acids Research 2021 Apr 19;49(7):4008-4019.

  6. Duan S, Gao W, Chen Z, Li Z, Li S, Gan J, Chen X,Li J*. Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex. Int J Biochem Cell Biol. 2020 Mar 29:105744. doi: 10.1016/j.biocel.2020.105744.

  7. Li Z#, Li L#, Huo Y, Chen Z, Zhao Y, Huang J, Jian S, Rong Z, Wu D, Gan J, Hu X*, Li J*, Xu XW*. Structure guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnology For Biofuels. 2020 Jun 15; 13:107.

  8. Chen Y, Liu H, Yang C, Gao Y, Yu X, Chen X, Cui R, Zhen L, Li S, Li X, Ma J, Huang Z, Li J*, Gan J*. Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues. Nature Communications 2019 Jan 23;10(1):387. doi: 10.1038/s41467-019-08296-w.

  9. Yang C, Wu R, Liu H, Chen Y, Gao Y, Chen X, Li Y, Ma J, Li J*, Gan J*. Structural insights into DNA degradation by human mitochondrial nuclease MGME1. Nucleic Acids Research 2018 Nov 16;46(20):11075-11088.

  10. Liu H, Wang R, Yu X, Shen F, Lan W, Haruehanroengra, P, Yao Q, Zhang J, Chen Y, Li S, Wu B, Zheng L, Ma J, Lin J, Cao C, Li J*, Sheng J*, Gan J*. High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Nucleic Acids Research 2018 Nov 30;46(21):11627-11638.




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