基本信息：
職稱：教授
職務：万博英超狼队网官方网 院長
電子郵箱：lluo@fudan.edu.cn
辦公地點：万博英超狼队网官方网 C105室
個人簡介：
羅淩飛 狗万外围充值 浩清特聘教授、万博体育分 院長。1999年畢業於南京大學獲學士學位，2004年畢業於德國哥廷根大學獲博士學位，2004-2006年在德國馬克斯普朗克生物物理化學研究所從事博士後研究工作。中國細胞生物學學會副理事長（2019-今），國家自然科學基金委員會生命科學部第六、七屆專家谘詢委員會委員（2014-2020）、第九屆國家傑出青年科學基金大評委會委員（2018-2020）。國家傑出青年科學基金獲得者（2009），國家級人才計劃入選者（2013、2019），中國青年五四獎章獲得者（2013），國務院特殊津貼獲得者（2019）。作為首席科學家或項目負責人先後主持國家“973計劃”項目（2008、2014）、國家自然科學基金重大項目（2021）和國家重點研發計劃項目（2021）。
研究方向：
器官再生修複及其發育生物學基礎：
本課題組以斑馬魚和小鼠為主要模式動物，以腦血管和消化器官再生修複機製及其發育生物學基礎和藥物開發為主要研究方向。近年來取得淋巴管和巨噬細胞在腦血管再生修複中的重要功能、肝髒重度損傷下由膽管細胞轉分化實現再生等重要原創性科學發現。目前課題組具體研究方向包括：1）消化器官再生的細胞與分子基礎及其藥物開發；2）腦血管再生修複的細胞與分子基礎及其藥物開發；3）消化器官發育的細胞譜係及命運決定機製研究；4）器官再生能力的物種差異及其形成機製。
Introduction and Research Interests
Dr. Lingfei Luo, Fudan-Haoqing Distinguished Professor, Dean of the School of Life Sciences, Fudan University. Dr. Luo got his bachelor degree from Nanjing University in 1999, and received his Ph.D. from the University of Goettingen, Germany, in 2004. Then, he obtained his postdoctoral training at the Max-Planck-Institute for Biophysical Chemistry in 2004-2006. He is currently the Vice President of the Chinese Society for Cell Biology, and has been the winners of the National Science Fund for Distinguished Young Scholars and China Youth May Fourth Medal. He has led several national major research project including 973 Program, NSFC Major Project, and National Key R&D Program.
Dr. Luo’s lab is focusing on the regeneration of brain vasculature and digestive organs as well as its developmental basis and drug development, using zebrafish and mouse as major model systems. Recent discoveries include novel roles of lymphatics and macrophages in brain vascular repair and regeneration, and the biliary-to-hepatocyte transdifferentiation to fulfill liver regeneration after extreme liver damages. There are four major directions in the lab: 1) Mechanisms of digestive organ regeneration and drug development. 2) Mechanisms of brain vascular regeneration and drug development. 3) Cell lineage and fate determination of digestive organ development. 4) Mechanisms underlying species difference of regenerative capabilities.
招生專業：
發育生物學、細胞生物學、遺傳學、生物化學與分子生物學、生理學、生物醫學
代表性論文：
1) 1）Yun Yang#, Shuang Li#, Lingfei Luo*. (2023). Responses of organ precursors to correct and incorrect inductive signals. Trends in Cell Biology (Online ahead of print) doi: 10.1016/j.tcb.2023.08.008. (IF: 21.2)
2）Pengcheng Cai#, Rui Ni#, Mengzhu Lv#, Huijuan Liu, Jieqiong Zhao, Jianbo He,Lingfei Luo*. (2023). VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis. Cell Reports42(9), 113028. (IF: 10.0)
3）Xiangyong Wei#, Xinmiao Tan#, Qi Chen#, Yan Jiang, Guozhen Wu, Xue Ma, Jialong Fu, Yongyu Li, Kai Gang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2023). Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish.Cell Reports42(7), 112660. (IF: 10.0)
4）Yun Yang#, Yuanyuan Li#, Jialong Fu#, Yanfeng Li, Shuang Li, Rui Ni, Qifen Yang, Lingfei Luo*. (2022). Intestinal precursors avoid being mis-induced to liver cells by activating Cdx-Wnt inhibition cascade. Proceedings of the National Academy of Sciences USA119(45), e2205110119. (IF: 12.8)
5）Junren Zhang#, Yang Zhou#, Shuang Li, Dashuang Mo, Jianlong Ma, Rui Ni, Qifen Yang, Jianbo He*, Lingfei Luo*. (2022). Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports39(1), 110596. (IF: 10.0)
6）Jingying Chen#, Xiuhua Li#, Rui Ni, Qi Chen, Qifen Yang, Jianbo He, Lingfei Luo*. (2021). Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell56(22), 3115–3127. (IF: 13.4)
7）Pengcheng Cai#, Xiaoyu Mao#, Jieqiong Zhao, Li Nie, Yan Jiang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2021). Farnesoid X Receptor is required for the redifferentiation of bi-potential progenitor cells during biliary-mediated zebrafish liver regeneration. Hepatology74(6),3345–3361. (IF: 17.3)
8）Yun Yang#, Hao Wang#, Jia He, Wenchao Shi, Zhanmei Jiang, Lina Gao, Yan Jiang, Rui Ni, Qifen Yang, Lingfei Luo*. (2021). A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proceedings of the National Academy of Sciences USA118(25), e2025793118. (IF: 12.8)
9）Jiaobo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai, Lingfei Luo*. (2019). Mammalian target of rapamycin complex 1 signaling is required for the dedifferentiation from biliary cell to bipotential progenitor cell in zebrafish liver regeneration. Hepatology70(6), 2092–2106. (IF: 17.3，封麵論文)
10）Jingying Chen, Jianbo He, Rui Ni, Qifen Yang, Yaoguang Zhang, Lingfei Luo*. (2019). Cerebrovascular injuries induce lymphatic invasion into brain parenchyma to guide vascular regeneration in zebrafish. Developmental Cell49(5), 697–710. (IF: 13.4，封麵論文)
11）Zigang Cao, Xiaoyu Mao, Lingfei Luo*. (2019). Germline stem cells drive ovary regeneration in zebrafish. Cell Reports26(7), 1709–1717. (IF: 10.0)
12）Chi Liu, Chuan Wu, Qifen Yang, Jing Gao, Li Li, Deqin Yang*, Lingfei Luo*. (2016). Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction. Immunity44(5), 1162–1176. (IF: 43.5)
13）Jianbo He, Huiqiang Lu, Qingliang Zou, Lingfei Luo*. (2014). Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology146(3), 789–800. (IF: 33.9，封麵論文)
14）Huiqiang Lu, Jun Ma, Yun Yang, Wenchao Shi, Lingfei Luo*. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Developmental Cell24(5), 543–553. (IF: 13.4)