李瑤

發布時間：2021-06-28瀏覽次數：5369

教師基本信息

姓名：李瑤（Yao Li）

職稱：教授（Professor）

職務：遺傳係主任（Head of the Department of Genetics）

電子郵箱：yaoli@fudan.edu.cn

辦公地點：狗万外围充值 江灣校區万博体育分 C517

辦公電話：021-31246559

研究方向

腫瘤功能基因組研究; 基因表達調控研究; 非編碼RNA的作用及機製研究

Functional genomics of tumours; regulation of gene expression; role and mechanism of non-coding RNAs.

授課情況

細胞生物學（Cell Biology）

招生專業

遺傳學（Genetics）

個人簡介

1982-1989年就讀万博英超狼队网官方网 ，1986年獲狗万外围充值 生物學學士學位，1989年獲狗万外围充值 生物學碩士學位，1989-1990年在四川四達生物工程公司從事生化製藥的產品開發工作。1990-1993年就讀万博英超狼队网官方网 ，1993年獲狗万外围充值 生物學博士學位，1993年至今狗万外围充值 生命學院任教。1995年在香港科技大學生物係作博士後，1997-1999年在美國美國紐約州立大學布法羅分校生物係作博士後，1996年任副教授，2003年任教授。共發表SCI論文125篇，其中通訊作者和第一作者共77篇，獲得授權專利20項，主編書籍5本，參編7本。

主持過國家重大專項、863項目、國自然基金麵上項目等10餘項國家級科研項目，和多項上海市項目。

Yao Li studied at the School of Life Sciences, Fudan University from 1982 to 1989, received her B.S. degree in Biology from Fudan University in 1986, and her M.S. degree in Biology from Fudan University in 1989, and was engaged in the product development of biochemical pharmaceuticals at Sichuan Sida Bioengineering Co. from 1989 to 1990.She received her PhD degree in Biology from Fudan University in 1993, and has been teaching in the School of Life Sciences of Fudan University since 1993, and was a postdoctoral fellow at the Department of Biology, The Hong Kong University of Science and Technology (HKUST) in 1995, and a postdoctoral fellow at the Department of Biology, State University of New York at Buffalo (SUNY-Buffalo) in 1997-1999. She has published 125 SCI papers, including 77 corresponding and first authors, 20 patents, 5 edited books and 7 co-edited books.

She has presided over more than 10 national research projects such as National Major Projects, 863 projects, and top-level projects of the National Natural Fund of China, as well as many projects in Shanghai.

獲獎情況

曾獲上海市科技進步一等獎、二等獎、教育部科學技術進步二等獎、江蘇省科技進步獎二等獎等。2010年獲全國勞模稱號。

She was awarded the first and second prizes of Shanghai Scientific and Technological Progress, the second prize of Scientific and Technological Progress of the Ministry of Education, the second prize of Jiangsu Scientific and Technological Progress Award, etc. In 2010, she was awarded the title of National Model Worker.

代表性論文：

  1. Kong Z, Lu Y, Yang Y, Chang K, Lin Y, Huang Y, Wang C, Zhang L, Xu W, Zhao S, Li Y. m6A-mediated biogenesis of circDDIT4 inhibits prostate cancer progression by sequestrating ELAVL1/HuR . Mol Cancer Res. 2023 Dec 1;21(12):1342-1355.  

  2. Liang Y, Lu Y, Chen Q, Cheng Y, Ma Y, Huang Y, Qiu M, Li Y. Identification of Long Noncoding RNAs That Exert Transcriptional Regulation by Forming RNA-DNA Triplexes in Prostate Cancer. Int J Mol Sci. 2023 Jan 19;24(3):2035.  

  3. K Feng K, Shi Q, Jiao D, Chen Y, Yang W, Su K, Wang Y, Huang Y, Zhang P, Li Y, Wang C. SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF. Cell Biosci. 2022 Dec 30;12(1):211.

  4. Huang W, Chen Q, Lu Y, Kong Z, Wan X, Huang Y, Qiu M, Li Y. Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer. Int J Mol Sci. 2022 Oct 13;23(20):12219.

  5. Lu Y, Lin Y, Zhang X, Yan J, Kong Z, Zhang L, Wang C, Huang Y, Zhao S, Li Y. LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription. Genes Dis, . 2022 Apr 26;10(2):317-320.

  6. Qin R, Zhao C, Wang CJ, Xu W, Zhao JY, Lin Y, Yuan YY, Lin PC, Li Y, Zhao S, Huang Y.Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation. J Immunother Cancer. 2021 Jul;9(7):e002840.

  7. Jiang M, Cheng Y, Wang D, Lu Y, Gu S, Wang C, Huang Y, Li Y. Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer. EBioMedicine. 2021 Jan;63:103150.

  8. Shi Q, Zhu Y, Ma J, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao SM, Huang H, Li Y, Ren S, Wang C，Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly. Mol Cancer. 2019 Nov 26;18(1):170.  


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