吳家雪

發布時間：2021-06-28瀏覽次數：4896

教師基本信息：

姓名：吳家雪

職稱：研究員

電子郵箱：jiaxue@fudan.edu.cn

辦公地點：万博英超狼队网官方网 A507室

辦公電話：021-31246554


研究方向

腫瘤發生發展和轉移的機理研究。以腫瘤細胞、模式動物和臨床樣本為模型，研究DNA損傷修複，信號轉導和翻譯後修飾（磷酸化和腺苷二磷酸核糖化）等在腫瘤（肝癌、肺癌）發生發展和複發轉移中的功能及分子機製，為腫瘤診療提供重要生物學標誌物和分子靶標。


個人簡介

2006年博士畢業於狗万外围充值 ，隨後赴美國密歇根大學從事博士後研究。2012年回國，任万博英超狼队网官方网 研究員，博士生導師。獲得教育部自然科學二等獎（第3完成人，2020）和複星醫藥獎。主持或參與國家重大科技專項課題和重點研發項目，以及基金委麵上項目。


授課情況

主講本科生選修課程《分子腫瘤學和遺傳學》


招生專業

遺傳學/細胞生物學


代表性論文和論著

  1. Huan Feng#, Juan Liu, Yangyang Qiu, Yao Liu, Hexige Saiyin, Xiao Liang, Feng Zheng, Ying Wang, Deke Jiang, Ying Wang, Long Yu, Wei Su, Suqin Shen*, Jiaxue Wu*. RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression. Oncogene, 2020 Aug;39(33):5495-5506

  2. Yahui Zhao#; Xiaoding Hu; Li Wei; Dan Song; Juanjuan Wang; Lifang You; Hexige Saiyin; Zhaojie Li; Wenbo Yu; Long Yu; Jin Ding; Jiaxue Wu*.PARP10 suppresses tumor metastasis through regulation of Aurora A activity. Oncogene, 2018.5, 37(22): 2921~2935

  3. Changjuan Shao #; Yangyang Qiu; Juan Liu; Huan Feng; Suqin Shen; Hexige Saiyin; Wenbo Yu; Youheng Wei; Long Yu; Wei Su; Jiaxue Wu*. PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2and regulating its stability. Cell Death and Disease, 2018.8.28, 9(9)

  4. Xiaoding Hu# ; Yahui Zhao; Li Wei; Bo Zhu; Dan Song; Juanjuan Wang;Long Yu; Jiaxue Wu *.CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis. Oncogene, 2017.07.13, 36(28): 4047~4059

  5. Hao Cai# ; Hexige Saiyin #; Xing Liu# ; Dingding Han# ; Guoqing Ji #;Bo Qin; Jie Zuo; Suqin Shen; Wenbo Yu; Jiaxue Wu* ; Yanhua Wu* ; Long Yu* .Nogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma. Molecular Oncology, 2018.12, 12(12): 2042~2054

  6. Jiaxue Wu#; Yibin Chen; Lin-Yu Lu; Yipin Wu; Michelle T Paulsen; Mats Ljungman; David O Ferguson; Xiaochun Yu *.Chfr and RNF8 synergistically regulate ATM activation. Nature Structural & Molecular Biology, 2011.6.26, 18(7): 761~768

  7. Chao Liu# ; Jiaxue Wu# ; Sharad C. Paudyal; Zhongsheng You; Xiaochun Yu*.CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Research, 2013.2.1, 41(3): 1698~1710

  8. Feng Zhang# ; Jianglin Ma# ; Jiaxue Wu# ; Lin Ye; Hong Cai; Bing Xia*;Xiaochun Yu*.PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Current Biology, 2009.3.24, 19(6): 524~529

  9. Jiaxue Wu# ; Linyu Lu; Xiaochun Yu*. Role of BRCA1 in DNA damage response. Protein Cell, 2010.2.1, 1(2): 117~123  

  10. Jiaxue Wu#; Michael S. Y. Huen; Lin-Yu Lu; Lin Ye; Yali Dou; Mats Ljungman; Junjie Chen; Xiaochun Yu*. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Molecular and Cellular Biology, 2009.2.1, 29(3): 849~860

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