姓名:張雪蓮
職稱:副教授(博士生導師)
電子郵箱:xuelianzhang@fudan.edu.cn
辦公地點:万博体育分 C501
辦公電話:021-31246587
研究方向:
主要從事結核病相關基礎和應用研究,包括蛋白翻譯後修飾調控結核杆菌感染致病的機製、結核杆菌與宿主細胞免疫互作機製,及抗結核新藥及耐藥機製方麵研究。
個人簡介:
2003南京農業大學動物醫學學院博士學位;2003-2005万博英超狼队网官方网 博士後;2005–至今,万博英超狼队网官方网 ,講師,副教授;2009- 2010 約翰霍普金斯大學公共衛生學院,訪問學者。
承擔項目:
主持國家自然科學基金5項,上海市及新疆建設兵團項目3項,參加國家重點研發計劃1項
2022.1-2026.12國家自然科學基金(麵上)
2020.1-2023.12國家自然科學基金(麵上)
2017.1-2020.12國家自然科學基金(麵上)
2013.1-2015.12國家自然科學基金(國際合作)
2010.1-2012.12國家自然科學基金(青年)
獲獎情況:
“結核杆菌耐藥性分析及結核病防控策略基礎研究” 獲上海市自然科學三等獎(2015)。獲得第三屆全國大學生生命科學創新創業大賽,指導教師一等獎(創新類)(2018)。
教學情況:
主講本科生通識核心課《微生物與人類健康》、《免疫與人類健康》、專業課《病原生物學基礎》
招生專業:
遺傳學、微生物學
代表性論文:
Luyao Bao#, JuanHu#, Bowen Zhan#, MingzheChi, Zhengyang Li, SenWang,Chan Shan, Zhaozhao Zhao, Yanchao Guo, Xiaoming Ding, Chaoneng Ji,Shengce Tao, Ting Ni, Xuelian Zhang*, Guoping Zhao*,Jixi Li*,Structural insights into RNase J that plays anessential role inMycobacterium tuberculosisRNA metabolism. Nature Communications, 2023,14:2280-2294
Yuchang Di, Siyue Xu, Mingzhe Chi, Youwei Hu, Xiao Zhang, Honghai Wang, Wenhong Zhang*, Xuelian Zhang*, Acetylation of cyclic adenosine monophosphate receptor protein by acetyl phosphate modulates mycobacteria virulence. Microbiology Spectrum, 2023,11(1):e0400222.
Weiheng Liao and Xuelian Zhang* Patpat: a public proteomics dataset search framework. Bioinformatics, 2023, 39(2): btad076.
Jianing Qian, Youwei Hu, Xiao Zhang, Mingzhe Chi, Siyue Xu, Honghai Wang,Xuelian Zhang*, Mycobacterium tuberculosis PE_PGRS19 induces pyroptosisthrough a non-Classical caspase-11/GSDMD pathwayin macrophages, Microorganisms 2022, 10, 2473-2487.
Qinglong Guo, Jing Bi, Honghai Wang,Xuelian Zhang*,Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis,Emerging Microbes &Infections,2021, 10(1):19-36.
Jing Bi (#),Zongchao Gou(#) , Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang, Xuelian Zhang *,Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia, Emerging Microbes & Infections, 2018, (7): 108~120.
Jianing Qian, Run Chen, Honghai Wang, Xuelian Zhang*, Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design, Frontiers in Cellular and Infection Microbiology 2020,10,article 594288.
Qinglong Guo, Jing Bi, Ming Li, Wenxue Ge, Ying Xu, Weixing Fan, Honghai Wang, Xuelian Zhang*, ESX Secretion-Associated Protein C from Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway, Frontiers in Cellular and Infection Microbiology, 2019,9,158-172.