張雪蓮

發布時間:2021-06-28瀏覽次數:3771

教師基本信息

姓名:張雪蓮

職稱:副教授(博士生導師)

電子郵箱:xuelianzhang@fudan.edu.cn

辦公地點:万博体育分 C501

辦公電話:021-31246587

研究方向:

主要從事結核病相關基礎和應用研究,包括蛋白翻譯後修飾調控結核杆菌感染致病的機製、結核杆菌與宿主細胞免疫互作機製,及抗結核新藥及耐藥機製方麵研究。

個人簡介:

2003南京農業大學動物醫學學院博士學位2003-2005万博英超狼队网官方网 博士後2005–至今,万博英超狼队网官方网 ,講師,副教授2009- 2010 約翰霍普金斯大學公共衛生學院,訪問學者。

承擔項目:

主持國家自然科學基金5項,上海市及新疆建設兵團項目3項,參加國家重點研發計劃1

2022.1-2026.12國家自然科學基金麵上

2020.1-2023.12國家自然科學基金麵上

2017.1-2020.12國家自然科學基金麵上

2013.1-2015.12國家自然科學基金國際合作

2010.1-2012.12國家自然科學基金青年

獲獎情況:

 “結核杆菌耐藥性分析及結核病防控策略基礎研究 獲上海市自然科學三等獎(2015獲得第三屆全國大學生生命科學創新創業大賽,指導教師一等獎(創新)(2018

教學情況:

主講本科生通識核心課《微生物與人類健康》、《免疫與人類健康》、專業課《病原生物學基礎》

招生專業:

遺傳學、微生物學

代表性論文:

  1. Luyao Bao#, JuanHu#, Bowen Zhan#, MingzheChi, Zhengyang Li, SenWang,Chan Shan, Zhaozhao Zhao, Yanchao Guo, Xiaoming Ding, Chaoneng Ji,Shengce Tao, Ting Ni, Xuelian Zhang*, Guoping Zhao*Jixi Li*Structural insights into RNase J that plays anessential role inMycobacterium tuberculosisRNA metabolism. Nature Communications, 2023,14:2280-2294

  2. Yuchang Di, Siyue Xu, Mingzhe Chi, Youwei Hu, Xiao Zhang, Honghai Wang, Wenhong Zhang*, Xuelian Zhang*, Acetylation of cyclic adenosine monophosphate receptor protein by acetyl phosphate modulates mycobacteria virulence. Microbiology Spectrum, 2023,11(1):e0400222.

  3. Weiheng Liao and Xuelian Zhang* Patpat: a public proteomics dataset search framework. Bioinformatics, 2023, 39(2): btad076.

  4. Jianing Qian, Youwei Hu, Xiao Zhang, Mingzhe Chi, Siyue Xu, Honghai Wang,Xuelian Zhang*, Mycobacterium tuberculosis PE_PGRS19 induces pyroptosisthrough a non-Classical caspase-11/GSDMD pathwayin macrophages, Microorganisms 2022, 10, 2473-2487.

  5. Qinglong Guo, Jing Bi, Honghai Wang,Xuelian Zhang*Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis,Emerging Microbes &Infections,2021, 10(1)19-36.

  6. Jing Bi (#),Zongchao Gou(#) , Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang, Xuelian Zhang *,Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia, Emerging Microbes & Infections, 2018, (7): 108~120.

  7. Jianing Qian, Run Chen, Honghai Wang, Xuelian Zhang*, Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design, Frontiers in Cellular and Infection Microbiology 2020,10,article 594288.

  8. Qinglong Guo, Jing Bi, Ming Li, Wenxue Ge, Ying Xu, Weixing Fan, Honghai Wang, Xuelian Zhang*, ESX Secretion-Associated Protein C from Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway, Frontiers in Cellular and Infection Microbiology, 2019,9,158-172.



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