姓名：周兆才
職稱：教授
E-mail: zhouzhaocai@fudan.edu.cn
辦公地點：發育生物樓334室
研究方向
長期關注組織器官間通訊與疾病特別是胃與腸、肝、腦等器官之間的相互作用與重塑，從上皮、間質、免疫、神經等不同類型細胞相互協同的角度闡釋胃腸組織穩態與疾病發生，從分子細胞信號機製的角度探索中樞及外周神經與胃癌發生發展的關係。近年來研究胃腸道腫瘤發生及免疫應答，代表性工作聚焦Hippo信號通路調控腫瘤發生及免疫應答的機製與功能，發現了一批疾病診斷標誌物和先導藥物，以通訊或共同通訊作者在Cancer Cell (2020/2014)、Nat Immunol (2015)、Nat Commun (2022/2017)、J Clin Invest (2022)、J Exp Med (2020/2018)、EMBO J (2020/2015) 、Cancer Res (2021)、Adv Sci (2021) 、Protein Cell (2023/2013)、Cell Res (2014/2012)、Cell Discov (2019)、Nano Lett (2021) 、Cell Rep (2012)等國際學術期刊發表研究論文80餘篇，參與編寫英文專著1部，申請發明專利10餘項。成果被Cell、Nature、F1000Prime等評價和推薦，多次應邀為Oncogene、Cellular Molecular Immunology、FrontiersCellDevelopmentalBiology等撰寫綜述或組織主題專刊，為國際學術會議做大會報告，為Nature Cell Biology、Nature Chemical Biology、Journal of Clinical Investigation、Journal of Experimental Medicine、Cell Research、ProteinCell等國際學術期刊審稿。
個人簡介
院長助理/國家傑青/科技部重點研發首席/中科院百人計劃優秀
2004年博士畢業於中國科學技術大學，隨後赴美國賓州大學（UPenn）從事博士後研究。2009年中國科學院“百人計劃”引進回國，曆任中科院上海生化與細胞所、分子生物學國家重點實驗室、細胞生物學國家重點實驗室研究員。2014年獲中科院百人計劃終期評估“優秀”，同年被授予中科院傑出青年科技創新人才稱號。2017年任中科院分子細胞科學卓越創新中心特聘研究員，同年獲國家自然科學基金委醫學部“傑青”資助。2020年任狗万外围充值 特聘教授，遺傳工程國家重點實驗室研究組長。擔任國家科技部 “發育和代謝：組織器官生長與尺寸控製” 重點專項首席科學家。主持國家自然科學基金委重點、重大、麵上及上海市重點等基金項目，並獲中科院戰略性科技先導專項資助。曾任中科院與高校聯合交叉創新團隊負責人（GPCR信號轉導）。擔任Frontiers in Immunology等學術期刊編輯；《細胞生物學》、《生命的化學》等期刊編委；上海市生物工程學會理事、中國抗癌協會腫瘤胃腸病學專業委員會委員、中國細胞生物學會醫學細胞生物學分會委員。
授課情況
癌生物學
招生專業
遺傳學
科研項目
主持國家重點研發計劃，國家自然科學基金等項目。
代表性論文
1. Meng Y, Ye F, Nie P, Zhao Q, An L, Wang W, Qu S, Shen Z, Cao Z, Zhang X, et al. Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells. J Hepatol. 2023. 79(6):1435-1449.
2. Jiao S, Li C, Guo F, Zhang J, Zhang H, Cao Z, Wang W, Bu W, Lin M, Lü J, et al. SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Nature Communications. 2023;14:6416.
3. Cao JJ, Ji LL, Zhan YX, Shao X, Xu PC, Wu BT, Chen P, Cheng LY, Zhuang XB, Ou Y, et al. MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages. Cellular & molecular immunology. 2023. 20(12):1413-1427.
4. Nie P, Zhang W, Meng Y, Lin M, Guo F, Zhang H, et al. A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer. Protein & cell. 2023, 14(7):513-31.
5. Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, et al. CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nat Commun. 2022, 13(1):4995.
6. Chen K, Tang Y, Wu M, Wan XC, Zhang YN, Chen XX, et al. Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability. Org Lett. 2022, 24(1):53-7.
7. An L, Cao Z, Nie P, Zhang H, Tong Z, Chen F, et al. Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers. J Clin Invest. 2022, 132(9).
8. Zhou Z, Yuan Z, Hong W, Wang W. Editorial: A Hippo's View: From Molecular Basis to Translational Medicine. Front Cell Dev Biol. 2021, 9:729155.
9. Zhang H, Lin M, Dong C, Tang Y, An L, Ju J, et al. An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh). 2021, 8(17):e2004850.
10. Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, et al. A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells. Cancer Res. 2021, 81(11):3036-50.
11. Li G, Hu X, Nie P, Mang D, Jiao S, Zhang S, et al. Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer. Nano Lett. 2021, 21(1):747-55.
12. Chen XX, Tang Y, Wu M, Zhang YN, Chen K, Zhou Z, et al. Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies. Org Lett. 2021, 23(20):7792-6.
13. An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. The Journal of experimental medicine 2020, 217(6): e20191817.
14. Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. The EMBO journal 2020, 39(7):e103255.
15. Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov 2019, 5:3.
16. Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. The Journal of biological chemistry 2019, 294(8):2744-2756.
17. Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z: Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine 2018, 215(2):699-718.
18. Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 2018, 293(37):14455-14469.
19. Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z: DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 2017, 36(30):4362-4369.
20. Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun 2017, 8:14058.
21. Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100. The Journal of biological chemistry 2015, 290(32):19558-19568.
22. Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al: Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling. The Journal of biological chemistry 2015, 290(44):26811-26820.
23. Shi Z, Jiao S, Zhou Z: Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 2015, 47(1):29-38.
24. Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 2015, 16(3):246-257.
25. Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al: A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO journal 2015, 34(23):2903-2920.
26. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 2014, 24(3):331-343.
27. Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al: Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 2014, 185(3):366-374.
28. Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z: Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1. The Journal of biological chemistry 2014, 289(52):35969-35978.
29. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al: A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer cell 2014, 25(2):166-180.
30. Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al: Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex*. Journal of Biological Chemistry 2014, 289(14):9651-9661.
31. Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al: Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 2013, 21(4):680-688.
32. Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al: Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 2013, 21(3):449-461.
33. Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z: Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 2012, 22(10):1440-1452.
34. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 2012, 1(6):665-675.