姓名：陸豔
職稱：副研究員
電子郵箱：lueyan@fudan.edu.cn
辦公地點：狗万外围充值 江灣校區生命科學樓A309
個人簡介
万博英超狼队网官方网 副研究員，博士生導師。2006年作為直博生進入狗万外围充值 學習，2012年獲狗万外围充值 遺傳學博士學位，隨後進入中國科學院上海生命科學研究院從事研究工作，曆任助理研究員、副研究員。2020年進入万博英超狼队网官方网 ，任副研究員。長期從事群體遺傳學和基因組學相關研究，近年來以第一作者或通訊作者在Nature, Cell Reports, National Science Review, Molecular Biology and Evolution, iScience, Genome Biology, Science China Life Sciences等國際權威雜誌上發表多篇SCI研究性論文。入選上海市青年科技英才“揚帆計劃”，主持國家自然科學基金青年項目、任國家重點研發計劃課題負責人和子課題負責人，研究成果入選F1000，中國生物信息學十大科學進展、中國生物信息學十大數據庫等。上海人類學學會“分子人類學”專業委員會秘書長、常務委員。
研究方向
1. “病原、媒介、宿主”的遺傳多樣性及共進化
2. 人群的遺傳結構及適應性進化
3. 感染性疾病的遺傳基礎和泛基因組研究
4. 生物信息數據庫和在線分析平台
招生專業
遺傳學 微生物學 生物信息學
代表性論文和論著
1. Yang Gao#, Xiaofei Yang#, Hao Chen#, Xinjiang Tan#, Zhaoqing Yang#, Lian Deng#, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Xiaohan Zhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Bingyin Shi, Li Jin, Zhibin Hu, Chinese Pangenome Consortium#, Yan Lu*, Jiayou Chu*, Kai Ye*, Shuhua Xu*, A pangenome reference of 36 Chinese populations. Nature, 2023
2. Qi Liu, Bo Xie, Yang Gao, Shuhua Xu*, Yan Lu*. A protocol for applying low-coverage whole-genome sequencing data in structural variation studies, STAR Protocols, 2023
3. Qi Liu, Ke Yang, Bo Xie, Yang Gao, Shuhua Xu*, Yan Lu*. Mapping Structural Variations in Haemaphysalis longicornis and Rhipicephalus microplus Reveals Vector-Pathogen Adaptation, iScience, 2023
4. Yuwen Pan, Jia Wen, Zhilin Ning, Yuan Yuan, Xubing Liu, Yajun Yang, Yaqun Guan, Yan Lu*, Dolikun Mamatyusupu, Shuhua Xu*. Comparative genomic and transcriptomic analyses reveal the impacts of genetic admixture in Kazaks, Uyghurs, and Huis, Molecular Biology and Evolution, 2023
5. Zeshan Lin#, Yan Lu#, Guoliang Yu; Huajing Teng, Bao Wang, Yajun Yang, Qinglan Li, Zhongsheng Sun, Shuhua Xu*, Wen Wang*, Peng Tian*. Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation, SCIENCE CHINA Life Sciences, 2023
6. Fang Luo#, Wenbin Yang#, Mingbo Yin, Xiaojin Mo, Yuhong Pang, Chengsong Sun, Bingkuan Zhu, Wei Zhang, Cun Yi, Zhidan Li, Jipeng Wang, Bin Xu, Zheng Feng, Yangyi Huang, Yan Lu*, Wei Hu*. A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching, Cell Reports, 2022, 39(1)
7. Yuwen Pan#, Chao Zhang#, Yan Lu#, Zhilin Ning, Dongsheng Lu, Yang Gao, Xiaohan Zhao, Yajun Yang, Yaqun Guan, Dolikun Mamatyusupu, Shuhua Xu. Genomic diversity and post-admixture adaptation in the Uyghurs,National Science Review, 2021
8. Hao Chen#, Yan Lu#, Dongsheng Lu, Shuhua Xu*. Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data, BMC Bioinformatics, 2021.
9. Chao Zhang#, Yang Gao#, Zhilin Ning#, Yan Lu#, Xiaoxi Zhang, Jiaojiao Liu, Bo Xie, Zhe Xue, Xiaoji Wang, Kai Yuan, Xueling Ge, Yuwen Pan, Chang Liu, Lei Tian, Yuchen Wang, Dongsheng Lu, Boon-Peng Hoh, Shuhua Xu*. PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biology,2019.20:215.
10. Lingxiang Wang#, Yan Lu#, Chao Zhang#, LanHai Wei#, Shi Yan, Yunzhi Huang, Chuanchao Wang, Swapan Mallick, Shaoqing Wen, Li Jin, Shuhua Xu*, Hui Li*. Reconstruction of Y-chromosome phylogeny reveals two neolithic expansions of Tibeto-Burman populations. Molecular Genetics and Genomics, 2018, 293:1293–1300
11. Chao Zhang#, Yan Lu#, Qidi Feng#, Xiaoji Wang#, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang and Shuhua Xu*, Differentiated demographic histories and local adaptations between Sherpas and Tibetans, Genome Biology, 2017, 18:115.
12. Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*, Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia, Molecular Biology and Evolution, 2017, 34(10):2572-2582.
13. Haiyi Lou#,Yan Lu#, Dongsheng Lu#, Ruiqing Fu#, Xiaoji Wang#, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*, A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence, Am.J.Hum.Genet, 2015, 97(1):54-66.
14. Yan Lu#, Shangling Pan#, Shuming Qin, Zhengdong Qin, Chuanchao Wang, Ruijing Gan, Hui Li, the Genographic Consortium, Genetic evidence for the multiple origins of Pinghua Chinese, Journal of Systematics and Evolution, 2013, 51(3):271-279.
15. Yan Lu#, Longli Kang#, Kang Hu, Chuanchao Wang, Xiaoji Sun, Feng Chen, Judith R Kidd, Kenneth K Kidd, Hui Li..High diversity and no significant selection signal of human ADH1B gene in Tibet, Investigative Genetics, 2012, 3:23.
16. Yan Lu, ChuanChao Wang, Zhendong Qin, Bo Wen, Sara E Farina, Li Jin, Hui Li. the Genographic Consortium, Mitochondrial Origin of the Matrilocal Mosuo People in China. Mitochondrial DNA, 2011, 23(1):13-19.
17. Longli Kang#, Yan Lu#, Chuanchao Wang, Kang Hu, Feng Chen, Kai Liu, Shilin Li, Li Jin, Hui Li. the Genographic Consortium, Y-chromosome O3 Haplogroup Diversity in Sino-Tibetan Populations Reveals Two Migration Routes into the Eastern Himalayas, Ann Hum Genet, 2011, 76(1):92-99