教師基本信息：
姓名：劉鐵民
職稱：教授
職務：生理學和神經生物學係係主任
電子郵箱：tiemin_liu@fudan.edu.cn
辦公地點：万博英超狼队网官方网 C113室
辦公電話：021-31246765
個人網頁/課題組主頁：//www.xahaidun.com/Data/View/2846
研究方向：
主要研究中樞神經及外周脂肪、肌肉、肝髒等組織在能量平衡和糖脂代謝調節中的重要作用，以組織特異性過表達或者敲除動物模型為研究對象，結合生理學和神經學來研究肥胖症、糖尿病及代謝綜合征的病理機製。著眼於將基礎科研中的新發現轉化為新穎的藥理和臨床幹預疾病等應用型研究。已在Cell，Cell Metabolism，Neuron，Nature Neuroscience等國際頂級刊物發表論文80多篇。是國家重點研發計劃“發育編程及其代謝調節”重點專項關於神經調控代謝領域的項目首席科學家。
個人簡介：
Dr. Tiemin Liu obtained his Ph.D. degree from the University of Toronto in 2009. From 2009 to 2014, Dr. Liu was a post-doctoral fellow at the Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, then at the UT Southwestern Medical Center and was promoted to be instructor in 2014. In 2017, Dr. Liu joined School of Life Sciences, Fudan University as a full professor and has served on the Head of Department of Physiology and Neurobiology since 2019. He was also an adjunct professor in Zhongshan Hospital in Fudan University. His research focuses on the anti-obesity neurocircuitry in the brain using conditional, neuron-specific genetic engineering techniques (Cre/loxP recombination) to regulate gene expression in the mouse brain. He currently extends his research interests to the brain regulation of peripheral tissues including adipose, muscle, liver, etc. He already published more than 80 papers including Cell, Cell Metabolism, Neuron, Nature Neuroscience, etc.
授課情況：
生理學專業前沿課程- BIOL737002
現代生物學基礎與前沿Ⅱ- BIOL620085
招生專業：
神經生物學，生理學，生物信息學，生物與醫藥
代表性論文和論著：
1. Lei Y, Liang X, Sun Y, Yao T, Gong H, Chen Z, Gao Y, Wang H, Wang R, Huang Y, Yang T, Yu M, Liu L, Yi CX, Wu QF, Kong X*, Xu X*, Liu S*, Zhang Z*, Liu T*, Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus, Cell Metabolism, 2024 Feb 6;36(2):438-453.
2. Zhao M, Ren Z, Zhao A, Tang Y, Kuang J, Li M, Chen T, Wang S, Wang J, Zhang H, Wang J, Zhang T, Zeng J, Liu X, Xie G, Liu P, Sun N, Bao T, Nie T, Lin J, Liu P, Zheng Y, Zheng X*, Liu T*, Jia W*. Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity. Cell Metabolism, 2024 Apr 3:S1550-4131(24)00089-5.
3. Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X, Liu T. Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila. Proc Natl Acad Sci U S A. 120(13):e2213857120，2023.
4. Kong X*, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T*, Rosen ED*. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. Cell Metabolism, 28(4):631-643, 2018.
5. Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X,Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons. Cell Reports 17;18(3):583-592, 2017.
6. Berglund ED*, Liu T*, Kong X*, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, and Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience, 17(7):911-3. 2014.
7. Liu T*, Kong D*, Shah BP*, Ye C*, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL and Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 73(3), 511-22, 2012.
a. Featured by Neuron as Cover: Neuron 73(3): 2012.
b. Featured Article by Neuron: Neuron 73(3): 2012.
c. Featured by Cell Metabolism with a preview: Transmitter Time: Synaptic plasticity and Metabolic Memory in the Hypothalamus. Cell Metabolism 15: 275-27 (2012).