孔星星

發布時間：2021-11-17瀏覽次數：5196



教師基本信息：

姓名：孔星星

職稱：教授

電子郵箱：kongxingxing@fudan.edu.cn

辦公地點：生科院D203

辦公電話：021-31246753


研究方向：組織器官代謝與網絡調控

個人簡介：

教育及工作經曆：

2021–至今 万博英超狼队网官方网 教授； 複旦附屬華山醫院 特聘教授

2017–2021美國加州大學洛杉磯分校 助理教授

2015–2017 哈佛大學貝斯以色列女執事醫學中心（美國）講師

2011–2015哈佛大學貝斯以色列女執事醫學中心（美國）博士後

2006-2011中國醫學科學院&北京協和醫學院 博士

2001-2006中國醫科大學 醫學本科


授課情況：專業英語


招生專業：生理


科研項目：國家自然科學基金委員會，重大研究計劃，92157203，骨骼肌幹擾素調節因子4(IRF4)對機體代謝穩態的功能機製研究，2022-01-01至2025-12-31，268萬元，在研，主持


代表性論文和論著：

第一作者或者通訊作者研究論文：

  1. Guo S, Feng Y, Zhu X, Zhang X, Wang H, Wang R, Zhang Q, Li Y, Ren Y, Gao X, Bian H #, Liu T #, Gao H #, Kong X#. Metabolic crosstalk between skeletal muscle and liver through IRF4-FSTL1 in NASH. Nature Communications. 14(1):6047, 2023. PMID: 37770480.

  2. Zhang S, Yan H, Ding J, Wang R, Feng Y, Zhang X, Kong X, Gong H, Lu X, Ma A, Hua Y, Liu H, Guo J, Gao H, Zhou Z, Wang R#, Chen P#, Liu T#, Kong X#. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. J. Cachexia Sarcopenia Muscle. 14(5):2126-2142, 2023. PMID: 37469245.影響因子=12.063

  3. Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X#, Liu T#. Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila. Proc Natl Acad Sci U S A. 120: e2213857120, 2023. PMID: 3694751. 影響因子=12.77

  4. Feng Y, Cui Z, Lu X, Gong H, Liu X, Wang H, Cheng H, Gao H, Shi X, Li Y, Ye H, Zhang Q#, Kong X#. Transcriptomics Dissection of Calorie Restriction and Exercise Training in Brown Adipose Tissue and Skeletal Muscle. Nutrients. 15: 1047, 2023. PMID: 36839405.影響因子=6.7

  5. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman S, Tontonoz P, Zhou Z, Liu T, Kong X. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes. 71:2256–2271, 2022. PMID: 35713959.影響因子=9.337

  6. Bao K*, Cui Z*, Wang H, Xiao H, Li T, Kong X#, Liu T#. Pseudotime Ordering Single-Cell Transcriptomic of β Cells Pancreatic Islets in Health and Type 2 Diabetes.Phenomics. 199-210, 2021.

  7. Zhu X*, Yao T*, Wang R*, Guo S, Wang X, Zhou Z, Zhang Y, Zhou X, Zhang Y, Zhuo X, Wang RT, Li ZJ#, Liu T#, Kong X#. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Advanced Science. 7(19):2001502, 2020. PMID: 33042761.影響因子=15.804

  8. Wang R*, Tian H*, Guo D, Tian Q, Yao T#, Kong X#. Impacts of Exercise Intervention on Various Diseases in Rats. J of Sport and Health Science. 9(3):211-227, 2020. (Review) PMID: 32444146. 影響因子=5.2，一區

  9. Kong X*#, Yao T*, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Tsai L, Kahn BB, Spiegelman BM, Liu T# and Rosen ED#. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. 28:631–643, 2018. (* 共同第一作者，#共同通訊作者) PMID:30078553. 影響因子=22.415

  10. Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM and Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 158(1), 69-83, 2014. PMID: 24995979. 影響因子=33.116

  11. Williams KW*#, Liu T*, Kong X*, Fakuda M*, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE and Elmquist JK. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism.20(3):471-82. 2014. (* 共同第一作者) PMID:25017942. 影響因子=18.878

  12. Berglund ED*, Liu T*, Kong X*, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Olson DP, Scherer PE, Lowell BB#, and Elmquist JK#. Melanocortin-4 receptors in preg Williams KW,anglionic parasympathetic and sympathetic neurons differentially control energy balance and glucose homeostasis. Nature Neuroscience. 17(7):911-3. 2014. (* 共同第一作者) PMID:24908101. 影響因子=16.095

  13. Eguchi J*, Kong X*, Tenta M, Wang X, Kang S, and Rosen ED. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes. 62(10):3394-403. 2013(* 共同第一作者) PMID: 23835343. 影響因子=8.474

  14. Kong X*, Wang R,Xue Y, Liu X, Zhang H, Chen Y,Fang F#, Chang Y#.Sirtuin 3, a new target of peroxisome proliferator-activated receptor-γ coactivator-1α, plays an important role in the suppression of reactive oxygen species. PLos One. 5(7): e11707, 2010.

  15. Kong X*, Wang R, Liu X, Zhu L, Shao D, Chang Y#, and Fang F#. Function of SIRT1 in Physiology.Biochemistry (Moscow). 74(7): 703–708, 2009. (review)

  16. Kong X*, Fan H*, Liu X, Wang R, Liang J, Gupta N, Chen Y#, Fang F#, Chang Y#. Peroxisome Proliferator-Activated Receptor Coactivator-1Enhances Antiproliferative Activity of 5-Deoxy-5-Fluorouridinein Cancer Cells through Induction of Uridine Phosphorylase. Mol Pharmacol.76:854–860, 2009. (* 共同第一作者)


（請提供中英文對照信息）

Name:Xingxing Kong, M.D., Ph.D


Address:         D203，2005 Songhu Road, Shanghai 200438, China

Work Phone:021-31246753

Work E-Mail:Kongxingxing@fudan.edu.cn


Education

China Medical University

(2001.9-2006.7) – Medical Doctor

Chinese Academy of Medical Sciences & Peking Union Medical College

(2006.9-2011.1) – Doctor of Philosophy



Professional Experience

Harvard Medical School and Beth Israel Deaconess Medical Center

(2011.2-2015.9) – Postdoctoral Fellow

Harvard Medical School and Beth Israel Deaconess Medical Center

(2015.10-2017.4) – Instructor

University of California, Los Angeles

(2017.5-2021.4) – Assistant Professor

Fudan University

(2021.4-  ) – Professor

Research Grants and Fellowships Received

2013- 2015: American Heart Association (AHA) Postdoctoral Fellowship, USA.

2015- 2019: NCRP Winter 2014 Scientist Development Award (15SDG25680028)–American Heart Association, Role: PI, Total: $ 308,000. (Declined)

2015- 2020: K99 Pathway to Independence Award (K99 DK106550-01), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Role: PI, Total: $927,000.

2022-2025: National Natural Science Foundation of China (92157203)，The role of IRF4 in skeletal muscle metabolism，Role: PI, Total: ￥2,680,000



Research papers- Peer Reviewed

  1. Kong X*, Fan H*, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y. Peroxisome Proliferator-activated Receptor {gamma} Coactivator-1 alpha enhances anti-proliferative activity of 5'-Deoxy-5-Fluorouridine in cancer cells through induction of Uridine Phosphorylase.Mol Pharmacol.76:854–860, 2009. (*, co-first author)

  2. Wang R, Kong X, Cui A, Liu X, Xiang R, Yang Y, Guan Y, Fang F, Chang Y. SREBP-1c Mediates the Effect of Insulin on the Expression of Cidea in Mouse Hepatocytes.Biochemical J.430(2): 245-254, 2010.

  3. Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y. PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα. Mitochondrion.10(5):516-27, 2010.

  4. Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, and Fang F.FoxO1 Represses LXRα-Mediated Transcriptional Activity of SREBP-1c Promoter.FEBS Lett. 22; 584(20):4330-4, 2010.

  5. Kong X, Wang R,Xue Y, Liu X, Zhang H, Chen Y,Fang F, Chang Y.Sirtuin 3, a new target of peroxisome proliferator-activated receptor-γ coactivator-1α, plays an important role in the suppression of reactive oxygen species.PLos One. 5(7): e11707, 2010.

  6. Eguchi J*, Kong X*, Tenta M, Wang X, Kang S, and Rosen ED. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization.Diabetes.62(10):3394-403. 2013(*, co-first author)

  7. Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot Jr. JJ, Rosen ED, Spiegelman BM. A Smooth Muscle-Like Origin for Beige Adipocytes. Cell Metabolism. 19(5):810-20, 2014. PMID: 24709624

  8. Berglund ED*, Liu T*, Kong X*, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, and Elmquist JK. Melanocortin-4 receptors in preganglionic parasympathetic and sympathetic neurons differentially control energy balance and glucose homeostasis. Nature Neuroscience.17(7):911-3. 2014. (* co-first author) PMID:24908101

  9. Williams KW*, Liu T*, Kong X*, Fakuda M*, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE and Elmquist JK. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism. 20(3):471-82. 2014. (* co-first author) PMID:25017942

  10. Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM and Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 158(1), 69-83, 2014. PMID: 24995979.

  11. Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED. IRF3 promotes adipose inflammation and insulin resistance and represses browning.J Clin Invest. 126(8):2839-54, 2016. PMID: 27400129.

  12. Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T, Williams KW. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons.Molecular Metabolism. 5(10):882-91, 2016. PMID: 27689001.

  13. Chen Q, Yang X, Zhang H, Kong X, Yao L, Cui X, Zou Y, Fang F, Yang J, Chang Y. Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.Biochim Biophys Acta. 1864(1):101-112, 2016. PMID: 27816442.

  14. Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons.Cell Reports. 18(3):583-592, 2017. PMID: 28099839.

  15. Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW. Ire1α in Pomc neurons is required for thermogenesis and glycemia.Diabetes. 66(3):663-673, 2017. PMID: 28028078.

  16. Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons.Cell Reports. 18(3):583-592, 2017. PMID: 28099839.

  17. Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci USA. 114(30):7981-7986, 2017. PMID: 28630339

  18. Kong X*#, Yao T*, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Tsai L, Kahn BB, Spiegelman BM, Liu T# and Rosen ED#. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. 28:631–643, 2018. (*, co-first author，#, co-corresponding author) PMID:30078553.

  19. Zhu X*, Yao T*, Wang R*, Guo S, Wang X, Zhou Z, Zhang Y, Zhou X, Zhang Y, Zhuo X, Wang RT, Li ZJ#, Liu T#, Kong X#. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Advanced Science. 7(19):2001502, 2020. PMID: 33042761.

  20. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman S, Tontonoz P, Zhou Z, Liu T, Kong X. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes. 71:2256–2271, 2022. PMID: 35713959.

  21. Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X#, Liu T#. Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila. Proc Natl Acad Sci U S A. 120: e2213857120, 2023. PMID: 3694751.

  22. Feng Y, Cui Z, Lu X, Gong H, Liu X, Wang H, Cheng H, Gao H, Shi X, Li Y, Ye H, Zhang Q#, Kong X#. Transcriptomics Dissection of Calorie Restriction and Exercise Training in Brown Adipose Tissue and Skeletal Muscle. Nutrients. 15: 1047, 2023. PMID: 36839405.

  23. Zhang S, Yan H, Ding J, Wang R, Feng Y, Zhang X, Kong X, Gong H, Lu X, Ma A, Hua Y, Liu H, Guo J, Gao H, Zhou Z, Wang R#, Chen P#, Liu T#, Kong X#. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. J. Cachexia Sarcopenia Muscle. 14(5):2126-2142, 2023. PMID: 37469245.

  24. Guo S, Feng Y, Zhu X, Zhang X, Wang H, Wang R, Zhang Q, Li Y, Ren Y, Gao X, Bian H #, Liu T #, Gao H #, Kong X#. Metabolic crosstalk between skeletal muscle and liver through IRF4-FSTL1 in NASH. Nature Communications. 14(1):6047, 2023. PMID: 37770480.




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